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Some members from the AAAP family namely the
2024-05-23
Some members from the AAAP family, namely the AUX1 and the LAX proteins, transport auxin instead of amino acids [48]. While there is some structural relationship between IAA and Trp, the substrate recognition characteristics seem different for these proteins: the auxins do not have any amino group o
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Alectinib is a second generation ALK antagonist that
2024-05-23
Alectinib is a second generation ALK antagonist that is built upon a 9-ethyl-6, 6-dimethyl-11-oxo benzo[b]carbazole scaffold (Fig. 5C) [58]. This drug is effective against the ALK L1196M gatekeeper mutation along with C1156Y and F1174L mutations [7]. The 11-oxo group of the drug forms a TCS PIM-1 1
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Previous studies to investigate the functions of
2024-05-23
Previous studies to investigate the functions of AHR in Treg Cyclopiazonic acid receptor have employed a loss-of-function approach, using AHR complete-null mice, or a gain-of-function approach by ligand administration. However, these approaches may confound the interpretation of the results. For ex
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tranylcypromine br Conclusion To conclude it
2024-05-23
Conclusion To conclude, it would be fair to say that the research efforts on FLAP inhibitors for intervening with LT biosynthesis have reached to a considerably advanced state during the last decade as a result of growing interest from both pharmaceutical industry and academia [4], [37], [38]. Du
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br Conflict of interest br Acknowledgments This
2024-05-23
Conflict of interest Acknowledgments This work was been partially supported by the following grants: C.I.S.I.A. project (Innovazione e Sviluppo del Mezzogiorno—Conoscenze Integrate per Sostenibilità ed Innovazione del Made in Italy Agroalimentare—Legge 191/2009) from the Italian Ministry of Ec
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GMX1778 receptor Ryoichi et al modified potent clinical
2024-05-23
Ryoichi et al. modified potent clinical candidate VX-680 (6) with 3-cyano-6-(5-methyl-3-pyrazolamino)pyridine as Aurora kinase inhibitor. Substituted cyano pyridine derivative (7) inhibited proliferation of HCT-116 cells with an IC50 value of 115 nM. It showed tumor inhibition in mice model at a dos
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Aminoglutethimide first generation aromatase inhibitor has
2024-05-22
Aminoglutethimide, first generation aromatase inhibitor, has been tried as an antiepileptic drug in combination with other standard drugs (Aguilar et al., 1961). Letrozole is a third generation reversible non-steroidal aromatase inhibitor, approved by US-FDA, for the treatment of postmenopausal wome
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In previous years evidence emerged that inferred secondary
2024-05-22
In previous years, evidence emerged that inferred secondary metabolites in plants might exhibit a potential arginase inhibition [36]. In a recent study, Pham and co-workers showed the inhibitory activity of chlorogenic pdgfr inhibitor (7) and piceatannol (8) (Fig. 3b) on mammalian arginase with IC5
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nmda receptor antagonist br Acknowledgment This study was su
2024-05-22
Acknowledgment This study was supported by Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research (KAKENHI) [grant number 15K15031]. Introduction Glioma is the leading malignancy of astrocyte origin in the brain. The most aggressive, invasive, and destructive glioma
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As the experimental procedure used could reflect
2024-05-22
As the experimental procedure used could reflect agonist-stimulation of both anterograde and retrograde APJ trafficking, as has been described for the δ-opioid peptide receptor (Zhang et al., 2006b, Zhang et al., 2006a), receptor internalization was more directly monitored by loading cell surface HA
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Methyllycaconitine citrate mg Although the earlier studies f
2024-05-22
Although the earlier studies focused on the antioxidant capacity of tocopherols, ascorbic Methyllycaconitine citrate mg and carotenoids, then it was noticed that phenolic compounds were more powerful than others (Rice-Evans, Miller, & Paganga, 1996). Phenolic compounds, the most numerous and ubiqui
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796 Prostate cell growth and prostate carcinogenesis
2024-05-22
Prostate cell growth and prostate carcinogenesis are not only mediated by androgens, they are also dependent on functional insulin receptor (IR) and insulin-like growth factor-1 (IGF-1) receptor (IGF1R) signaling. Previous studies addressed this issue and reported a correlation between high insulin
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Based on structure activity relationship
2024-05-22
Based on structure activity relationship of several SARM templates, Ligand Pharmaceuticals chose LGD2226 as their first clinical candidate (Miner et al., 2007). Although LGD2226 demonstrated myo- and osteo-anabolic activity and maintenance of sexual function in various preclinical models, the develo
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The findings from our previous study indicate that
2024-05-22
The findings from our previous study indicate that mitochondrial biogenesis of astrocytes is increased under experimental septic condition [25]. Recent studies have shown that IL-6 can activate AMPK by increasing the concentration of AMP [26], while AMPK regulates mitochondrial biogenesis and autoph
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In large biopsies series from ALK NSCLC treated patients
2024-05-22
In large biopsies series from ALK+ NSCLC treated patients, the number of detected mutations increased after second generation ALKi (Gainor et al., 2016) and in one study were present in 56% of the entire cohort (Shaw et al., 2013b). For example, the rate of G1202R mutations increases from 2% in pos
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