• Romiplostim is an Fc fusion

  2019-06-11

  

  Romiplostim is an Fc-fusion protein that augments thrombopoiesis by binding to and activating the thrombopoietin receptor. It is approved for the treatment of thrombocytopenia in patients with chronic immune thrombocytopenic purpura who have had an insufficient response to corticosteroids, immunoglo

• br Among the most important findings to have

  2019-06-11

  

  Among the most important findings to have emerged from the massive 2013–16 outbreak of Ebola virus disease in west Africa is the delayed clearance of virus from the semen of men who survived the disease and the consequent risk of sexual transmission of the virus, although this seems to be rare. In

• WHO estimates that of people

  2019-06-11

  

  WHO estimates that 30–50% of people with tuberculosis are untreated, in part because of underdiagnosis. Patients with undiagnosed (or diagnosed and untreated) tuberculosis are most likely to transmit infection, so strategies to reduce disease burden should focus on improving the pathway to care for

• It is recommended that pilsicainide

  2019-06-11

  

  It is recommended that pilsicainide be administered over 10min, with 1.0mg/kg being the maximum daily dosage allowed. However, a single oral dose of pilsicainide has been shown to be effective, feasible and safe, and the single dose is always from 100 to 150mg [4,10]. Both the time to maximum drug c

• br Conflict of interest statement br

  2019-06-11

  

  Conflict of interest statement Acknowledgments The authors would like to thank Dr. Bjørn Naume, and Dr. Erik Løkkevik from the Department of Clinical Oncology, the Norwegian Radium Hospital for their helpful comments. This study was supported by grants from the Norwegian Radium Hospital Founda

• An interesting finding in the study of Ngabo and colleagues

  2019-06-10

  

  An interesting finding in the study of Ngabo and colleagues was that, after a huge drop in the number of admittances to hospital for rotavirus in 2013, there was no further fall the next year. As the researchers discuss, this finding might herald the beginning of a biennial pattern of rotavirus acti

• LQT can have numerous clinical manifestations ranging from n

  2019-06-10

  

  LQT1 can have numerous clinical manifestations, ranging from no symptoms to sudden cardiac death, which reflects the heterogeneity in channel dysfunction. Mutation type, location, and even a patient׳s ethnic background, age, and gender are critical factors that affect the pathophysiology of the dise

• cyclosporin Preamble The J wave syndromes

  2019-06-10

  

  Preamble The J-wave syndromes (JWSs), consisting of the Brugada syndrome (BrS) and early repolarization syndrome (ERS), have captured the interest of the cardiology cyclosporin over the past 2 decades following the identification of BrS as a new clinical entity by Pedro and Josep Brugada in 1992 [

• La antinomia de los signos d a y noche que

  2019-06-10

  

  La antinomia de los signos “día” y “noche”, que comienza desde las metáforas del título, sugiere una rotación que se opera en el orden cósmico. El momento diurno tiene que ceder necesariamente el paso AL 8697 la noche, en una sucesión sin la cual cada uno de los elementos tomado aisladamente perderí

• Having to seek various approvals

  2019-06-10

  

  Having to seek various approvals, with no communication between RECs and no plan for which committee\'s decisions take priority, can lead to research bottlenecks. Many RECs, particularly those in low-income and middle-income countries (LMICs), have long turnaround times, perhaps because of infrequen

• El ansia renovadora que suscita tambi n se crea

  2019-06-10

  

  El ansia renovadora que suscita también se crea y re-crea en los paratextos ilustrados, que en cierto modo también sugieren una performatividad discursiva aplicada a la realidad convulsa de México en la revista Futuro, que puede observarse en la imagen y que se ha titulado, “Defensores del orden”.

• En el documental Tacos altos

  2019-06-10

  

  En el documental Tacos altos en el barro (Rolando Pardo, 2014), una de las travestis afirma que “somos seres humanos igual que ustedes”, mientras se esparce una crema por su rostro, rodeado de carencias económicas y de infraestructura de todo tipo. Esta cinta se ocupa de la relación entre prostituci

• br Discussion CML was the first malignancy

  2019-06-10

  

  Discussion CML was the first malignancy to be linked to a clear genetic abnormality, the Philadelphia chromosome. This chromosomal abnormality is so named because of the city in which it was first discovered and described in 1960 by Peter Nowell and David Hungerford [1]. The fusion protein result

• The estimated annual burden of injury

  2019-06-10

  

  The estimated annual burden of injury in rural Bangladesh revealed by this study was striking; 44 050 deaths and 21 million people suffering major injury events annually that were severe enough for them either to be unable to go to work or school for a day, or severe enough for them to seek treatmen

• br Methods br Results br Discussion One of

  2019-06-10

  

  Methods Results Discussion One of the hallmarks of cancer is the ability of cancer glycine receptors to evade apoptosis. Inhibition of apoptosis not only enhances the survival of cancer cells but also facilitates their escape from chemotherapy [5]. Therefore, apoptosis regulatory mechanism

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