• To obviate the mitogenic FGF activity several engineered

  2022-06-06

  

  To obviate the mitogenic FGF19 activity, several engineered FGF19 variants have been generated aiming to maintain the metabolic activity excluding the protumorigenic ones. One variant, M70, that differs from wild-type FGF19 by 5-amino acids deletion at the N-terminus and the substitution of 3-amino

• Recent studies have elucidated a profound role for

  2022-06-06

  

  Recent studies have elucidated a profound role for FFA4 in modulation of metabolism and energy utilization as well as endocrine and immune function, and as a consequence, have thrust FFA4 to the forefront of drug discovery efforts. For example, activation of FFA4 by fatty protease inhibitors hiv or

• Introduction High mobility group box HMGB

  2022-06-06

  

  Introduction High mobility group box 1 (HMGB1) is a nuclear protein that plays a fundamental role in the regulation of DNA-associated events such as DNA repair, transcription, and replication. HMGB1 can be translocated to the cytosol, plasma membrane, and extracellular space in response to various

• br Introduction Fructose bisphosphatase FBPase EC catalyses

  2022-06-06

  

  Introduction Fructose 1,6-bisphosphatase (FBPase; EC 3.1.3.11) catalyses the irreversible reaction of hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate [1]. Genetic and kinetic studies so far have demonstrated that at least two distinct isoenzymes of FBPase e

• ATN Ac PHSCN NH is a small

  2022-06-06

  

  ATN-161 (Ac-PHSCN-NH2) is a small peptide antagonist of integrin α5β1, a recently developed anticancer drug that interacts with the N-terminus of the β1 region of integrin α5β1 to lock integrin α5β1 in its non-activated conformation (Wang et al., 2016). The drug has been tested in Phase 2 clinical t

• While histone modifications can alter inter nucleosomal

  2022-06-06

  

  While histone modifications can alter inter-nucleosomal interactions that govern the compaction state of a chromatin fiber (Francis et al., 2004, Kalashnikova et al., 2013, Lu et al., 2008), the potential impact of histone modifications on higher-order chromosome organization beyond chromatin-fiber 

• Acetylation of histones by histone acetyltransferases stimul

  2022-06-06

  

  Acetylation of histones by histone acetyltransferases stimulates gene expression by relaxing am580 receptor structure, allowing access of transcription factors to DNA, whereas deacetylation of histones by histone deacetylases promotes chromatin condensation and transcriptional repression. Recent st

• A second H R antagonist with benzamide

  2022-06-06

  

  A second H3R antagonist with benzamide-based structure from Johnson & Johnson is JNJ-31001074, known as Bavisant and under chemical IUPAC name of (4-cyclopropylpiperazin-1-yl)-[4-(morpholin-4-ylmethyl)phenyl]methanone. It is a compound with molecular weight 329.44, HBA four, and MLogP 1.52 encompass

• br Conclusion br Acknowledgement br Introduction Biogenic am

  2022-06-06

  

  Conclusion Acknowledgement Introduction Biogenic amine histamine is synthesized from L-histidine by histidine decarboxylase (HDC). Histamine is involved in a wide variety of pathological and physiological processes including allergic reactions, inflammation, immune responses, gastric secret

• The metal nanoparticles of gold Au silver Ag

  2022-06-06

  

  The metal nanoparticles of gold (Au), silver (Ag), Platinum (Pt), Palladium (Pd) and/or their composites are also being widely used to develop electrochemical sensors because of their unique advantages such as (i) ease in immobilization of receptor molecules, (ii) catalysis of electrochemical reacti

• DDD107498 sale YAP TAZ nuclear function is also influenced b

  2022-06-06

  

  YAP/TAZ nuclear function is also influenced by interaction with the TEAD family of transcription factors [96, 97, 98, 99, 100, 101]. The RAC1 DDD107498 sale exchange factor protein TIAM1 has recently been linked to YAP/TAZ regulation in the nucleus and cytoplasm. Nuclear TIAM1 inhibits YAP/TAZ bind

• Based on the in vitro findings summarized

  2022-06-05

  

  Based on the in vitro findings summarized here, we posited that, in the intact brain, release of ROS from iron-laden astrocytes to the local neuropil elicits oxidative damage and degeneration of indigent dopaminergic projections and other vulnerable neuronal elements (Schipper, 2001). Of particular

• As well as the above studies Meier and coworkers

  2022-06-05

  

  As well as the above studies, Meier and coworkers used TUG-891, alongside omega-3 fatty acids, to show a potential role for FFA4 in inhibiting proliferation of DU145 prostate cancer cells [68]. Given that these cells express both FFA4 and FFA1 and the current view that TUG-891 may not be sufficient

• br Materials and methods br Results br Discussion ENU

  2022-06-05

  

  Materials and methods Results Discussion ENU mutagenesis is a powerful approach to identify novel genes or LY2784544 to dissect the molecular basis of mammalian immune system (Siggs, 2014). T cells are critical components in the host defense against pathogens, and their activity has to be

• AVE 0991 mg Little is known about the endocrinological contr

  2022-06-05

  

  Little is known about the endocrinological control of reproduction in polychaetes. In vertebrates, gonadal maturation is regulated by the hypothalamo-pituitary-gonadal axis. GnRH, GTHs, and steroid hormones are involved in this axis (see Okubo and Nagahama, 2008). In two polychaete species, Perinere

14908 records 364/994 page Previous Next First page 上5页 361362363364365 下5页 Last page