• br Results br Discussion Using a

  2022-01-29

  

  Results Discussion Using a novel viral vector for norepinephrine-targeted gene deletion, we have shown that glucocorticoid receptor topirimate from locus coeruleus norepinephrine neurons reduces social interaction specifically in female mice. This effect is not attributable to changes in nove

• It is generally considered that elevated blood glucose due t

  2022-01-29

  

  It is generally considered that elevated blood glucose due to insulin resistance is an important factor in islet compensation to high fat feeding [27]. However, we have shown recently that insulin resistance induced in mice by hydrocortisone injection provokes significant islet Protease Inhibitor Co

• br Results br Discussion In this study we

  2022-01-29

  

  Results Discussion In this study, we investigated the role of galanin and GAL2 receptors on anxiety-like behaviours mediated by the dorsal hippocampus of rats. We showed that locally administered galanin (1 nmol) decreased exploration of the open arms in the EPM, suggesting an anxiogenic-like

• In this study an galactosidase gene GalA from a

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  In this study, an α-galactosidase gene, GalA, from a Aspergillus oryzae strain RIB40 [14] was artificially synthesized. To produce high levels of secretory expression in Pichia and facilitate its industrial application, we systematically investigated the gene dosages and the role of the ERSAs, namel

• Considering the conformational preferences of the

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  Considering the conformational preferences of the SRSRY sequence in the x-ray structures of soluble uPAR (SuPAR) [18], [19], [20], [50], [51], it is included in a quite flexible linker delimited by Cys76 and Cys95 residues. The SRSRY sequence adopts either α-turned or β-extended conformation. In any

• A large body of literature have reported that

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  A large body of literature have reported that various cellular pathways are dysregulated in NPC [19]. Among these pathways, Akt is frequently hyperactivated in NPC and regulates diverse cellular processes including tumor cell growth, proliferation, metabolism, survival and invasion, as well as angio

• Introduction Pneumocystis pneumonia PCP is

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  Introduction Pneumocystis pneumonia (PCP) is a respiratory invasive infection caused by Pneumocystis jirovecii, an ubiquitous fungus. It is transmitted by air and mostly infects immunocompromised patients. PCP is characterized by respiratory complaints of cough, dyspnea, but also tachycardia, low g

• Several studies have indicated that

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  Several studies have indicated that PLD-regulated PA signaling intersects with Rho-mediated cytoskeletal remodeling to drive mesenchymal-like cellular features, and it is known that Rho signaling has the potential to induce YAP/TAZ nuclear activity. Accordingly, Han et al. (2018) provide evidence th

• br Acknowledgements This work was financially supported by t

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  Acknowledgements This work was financially supported by the National Natural Science Foundation of China (Grant No. 81803033) and the “Double First-Class” University project (CPU2018GF02). Introduction Atrial fibrillation (AF) is the most common progressive cardiac rhythm disorder. Studies ha

• br Patients and methods br Results br Discussion The positiv

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  Patients and methods Results Discussion The positivity of serum anti-HBc is the most commonly used marker to confirm the history of HBV infection. Quantification of serum anti-HBc has been explored as a marker of HBV-induced hepatitis and the adaptive immune response against HBV infection a

• 4-Aminobutyric acid In summary we propose a model that expla

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  In summary, we propose a model that explains the possible mechanism the HULC mediates activation of HBV in liver cancer 4-Aminobutyric acid (Fig. 8). In the model, HULC promotes the expression of miR-539 by stimulating HBx-co-activated STAT3. Then, miR-539 down-regulates APOBEC3B, leading to an inc

• Previous studies have established that phosphorylation of GC

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  Previous studies have established that phosphorylation of GC-B is required for activation of GC-B. Conversion of all six chemically determined serine and threonine phosphorylation sites in GC-B to alanines produced a properly folded enzyme that retained GC activity under synthetic detergent activati

• Although we showed that RBL H Sc cells

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  Although we showed that RBL-2H3 Sc98 Phosphatase Inhibitor Cocktail (2 Tubes, 100X) mg took up histamine from the microenvironment, it was unclear which transporter mediated its passage across the plasma membrane. Other biogenic amines have selective transporters that belong to the neurotransmitter

• ABT-199 australia Free d glutamate also has been found

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  Free d-glutamate also has been found in various tissues of invertebrates and vertebrates including mammals (Han et al., 2011; Ariyoshi et al., 2017), fish (Kera et al., 2001) amphibians (Kera et al., 2001), birds (Kera et al., 2001), mollusks (Tarui et al., 2003; Patel et al., 2017) and arthropods (

• Introduction Erythrocyte membrane proteins or their ortholog

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  Introduction Erythrocyte membrane proteins or their orthologs are found in almost all Ginsenoside Rd synthesis of the body [1,2]. Because of this compositional similarity and the erythrocyte membrane's accessibility, the red blood cell membrane (RBCM) has served as a crude model for mammalian plas

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