• Since ET was discovered first and showed a wide

  2021-03-10

  

  Since ET-1 was discovered first and showed a wide variety of actions not only on the cardiovascular system but also on various other tissues, much information has accumulated on ET-1 compared with the two other peptides. The method for measurement of ET-1 levels in plasma or various tissues by means

• br Introduction Epidermal growth factor receptor EGFR activa

  2021-03-10

  

  Introduction Epidermal growth factor receptor (EGFR)-activating-mutant non-small cell lung cancer (NSCLC) often initially responds well to EGFR tyrosine kinase inhibitors (TKIs) (Haber et al., 2011); however, the disease almost always recurs about 10–13 months of therapy. Analysis of clinical spe

• br Enzymes repairing alkylated DNA br Induction of the

  2021-03-09

  

  Enzymes repairing alkylated DNA Induction of the Ada regulon Methylated Ada is a strong activator for ada and alkA promoters. Although much weaker than the methylated form, unmethylated Ada acts alone as an activator for ada and alkA promoters. In contrast, the unmethylated protein present in

• Our western blotting results showed that phospho DDR

  2021-03-09

  

  Our western blotting results showed that phospho-DDR1 levels continued to increase after I/R injury, and the overall activation trend between phospho-DDR1 and MMP-9 was the same. We found that phospho-DDR1 expression started to increase significantly at 12h after I/R injury, which may be related to

• Uracil residues incorporated into DNA exist transiently sinc

  2021-03-09

  

  Uracil residues incorporated into DNA exist transiently since they are subject to removal by the multi-step uracil-initiated DNA Nivolumab excision repair (BER) process [2], [14]. In E. coli, uracil-DNA BER is initiated by uracil-DNA glycosylase (Ung), which catalyzes the hydrolytic cleavage of the

• A third aim of our investigation was to evaluate

  2021-03-09

  

  A third aim of our investigation was to evaluate the impact of the methylation profile of p15, p16, p53, and DAPK, individually or combined, on progression-free and overall survival. We did not find any statistically significant difference in progression-free survival and overall survival in MM case

• br Results On the th day the horizontal

  2021-03-09

  

  Results On the 8th day, the horizontal (Fig. 1) and vertical locomotor activity (Fig. 2) and the dorsal (Fig. 3) and STI571 striatal dopamine release (Fig. 4) increased significantly in nicotine-treated rats, compared with the saline-treated rats. Tukey post-hoc test revealed the following p val

• During recent years two primary types of models have been

  2021-03-09

  

  During recent years, two primary types of models have been applied for calculating various thermodynamic properties of amino tropisetron solutions, i.e. excess Gibbs energy (gE) models used numerously to describe the solubility of amino acid solutions, and equations of state (EOS) models appropriat

• br Conclusion and future perspectives LDL cholesterol loweri

  2021-03-09

  

  Conclusion and future perspectives LDL cholesterol-lowering therapy is essential for cardiovascular risk reduction. On the background of a high inter-personal variation of cholesterol synthesis and cholesterol DC260126 the efficacy of cholesterol lowering, both, with statins and with ezetimibe e

• Radezolid First of all two assumptions just as

  2021-03-09

  

  First of all, two assumptions just as in Ref. [30] are need to simplify the penetration process: (1) The crater phases is short and the Radezolid of EFP is consumed little; thus, the influence of crater on penetration can be ignored; (2) the initial stagnation radial pressure is equal to axial pres

• To identify and characterize new possible

  2021-03-09

  

  To identify and characterize new possible molecular targets, the mechanisms of various kinds of TCDD toxicities that occur by abnormal regulation in the downstream of AhR signals have been studied (Yoshioka et al., 2011). Experimental evidence has revealed that prostanoids (i.e., prostaglandins and

• The quaternary structure of many of

  2021-03-08

  

  The quaternary structure of many of the family B members (i.e., secretin, glucagon, glucagon-like peptide and SGC707 receptors) have been actively studied and it has been demonstrated that they can form homodimers/oligomers (Gao et al., 2009; Ng & Chow, 2015; Ng, Lee, & Chow, 2013). Harikumar, Pino

• Imipenem DGK is highly expressed in skeletal muscle which is

  2021-03-08

  

  DGKδ is highly expressed in skeletal muscle [7], which is a primary target of insulin for glucose disposal [14]. Notably, Chibalin et al. reported that DGKδ contributes to hyperglycemia-induced peripheral insulin resistance and that decreased protein levels of DGKδ in skeletal muscle attenuated gluc

• Interestingly some drugs have been shown

  2021-03-08

  

  Interestingly, some drugs have been shown to be effective in the regulation of cytokine production (such as IL-2, IL-10, IL-27, IL-35, IL-37 and transforming growth factor-β, TGF-β) and, therefore, having a key role in the management of certain inflammatory-based clinical conditions (Banchereau et

• Increasing evidence suggests that normal vaginal delivery is

  2021-03-08

  

  Increasing evidence suggests that normal vaginal delivery is a natural inflammatory process which results in increased levels of cytokines like Interleukin-6 (IL-6), Interleukin-8 (IL-8) in maternal and cord blood plasma [10]. Increased levels IL-6 and IL-8 have been reported in the amniotic fluid o

14823 records 633/989 page Previous Next First page 上5页 631632633634635 下5页 Last page