• Previous studies have documented that SCFAs

  2020-11-19

  

  Previous studies have documented that SCFAs may elicit effects on lipid metabolism via de novo synthesis and transport. Acetate is not only used as an energy source, but is also constituted as a substrate for the cholesterol synthesis in the liver through acetyl-CoA, thus affecting plasma cholestero

• br Conclusion In summary a novel and label free

  2020-11-18

  

  Conclusion In summary, a novel and label-free fluorescence assay was developed for detection of Cu2+ and galactose oxidase using water-dispersible homogenous alloyed CdZnTeS QDs. The CdZnTeS QDs were firstly synthesized via a simple one-pot hydrothermal route using DMSA as the S source, surface l

• br Structure of USP Schematic representation of

  2020-11-18

  

  Structure of USP7 Schematic representation of the USP7 domain architecture is shown in Fig. 3B. USP7 is a 135 kDa protein that consists of seven domains, including the N-terminal TRAF-like (Tumor necrosis factor Receptor–Associated Factor) domain, followed by the catalytic core domain and the fiv

• Altogether the results of this study demonstrate that

  2020-11-18

  

  Altogether, the results of this study demonstrate that peripheral blockade of both ETA and ETB receptors reduces tumor-induced facial heat hyperalgesia and increased spontaneous grooming, without modifying ongoing nociception. It is possible to suggest that bosentan is acting upon both receptors pre

• Enhanced responses to varying concentrations of bronchoconst

  2020-11-18

  

  Enhanced responses to varying concentrations of bronchoconstrictors, such as MCh, and airway obstruction are characteristic of caudatin and common to other clinical states, including chronic obstructive pulmonary disease, lung transplantation, and infection- or chemical agent-induced airway inflamm

• During the past few years several

  2020-11-18

  

  During the past few years, several studies have addressed macrophage phenotype in experimental models, such as angiotensin II-induced AAA. A first study investigated macrophage phenotype using flow cytometry to identify M1 and M2 macrophages and qPCR analysis for expression of NOS2 and Ym1/2. The au

• br DDR mediated signaling DDRs

  2020-11-18

  

  DDR-mediated signaling DDRs initiate signaling pathways in a context and cell type-dependent manner. For instance, DDR1 was reported to activate ERK in vascular smooth muscle gap27 (Lu et al., 2011), to inhibit ERK in mesangial cells (Curat and Vogel, 2002), and to have no effect on ERK activati

• Introduction Protein ubiquitination is a posttranslational m

  2020-11-18

  

  Introduction Protein ubiquitination is a posttranslational modification that plays a major role in almost all cellular processes in eukaryotes (Hochstrasser, 2009; Komander & Rape, 2012). It involves the covalent attachment of ubiquitin (Ub) via its C-terminal glycine carboxylate to a primary amine

• DGK type I http www apexbt com

  2020-11-18

  

  DGKη1 (type II DGK) has a separated catalytic domain [10], [13], whereas the domains of DGKα, ε and ζ are not split [1], [2], [3], [4], [5]. Therefore, the structural difference may cause the distinct affinity for DG among these isozymes. Because other type II DGKs (η2, δ1, δ2 and κ) also have the s

• In this context we initiated a

  2020-11-17

  

  In this context, we initiated a program to develop new antiviral chemotypes towards a host factor implicated in Benzoylmesaconitine replication: the host (human) dihydrofolate reductase (DHFR) [21]. We recently identified this enzyme as the molecular target of 1-aryl-4,6-diamino-1,2-dihydrotriazine

• br Introduction Lung cancer is the leading

  2020-11-17

  

  Introduction Lung cancer is the leading cause of cancer-related death worldwide, accounting for more than 1.5 million deaths in 2012. Non–small-cell lung cancers represent approximately 85% of lung neoplasms; among these, squamous cell carcinomas (SCC) account for approximately 30% of cases. The

• Some mechanistic experiments performed in the early

  2020-11-17

  

  Some mechanistic experiments performed in the early 2000s by Ongusaha et al. [78], suggest that DDR1 induction protects z vad fmk from apoptosis in a p53-dependent manner, and that impairment of DDR1 expression or function leads to a pronounced increase of DNA damage-induced apoptosis. This evidenc

• Many filarial species harbor an endosymbiotic bacterium

  2020-11-17

  

  Many filarial species harbor an endosymbiotic bacterium of the genus Wolbachia. A recent investigation of Wolbachia distribution in 35 filarial species including 28 species and 7 genera and/or subgenera have shown that 37% of them harbor Wolbachia (Ferri et al., 2011). In filarial nematodes, Wolbach

• Six substrate recognition sites SRS SRS have

  2020-11-17

  

  Six substrate recognition sites (SRS1-SRS6) have been identified at positions 102-123, 204-209, 238-244, 301-319, 374-382 and 483-492 (Table 2, underlined residues) based on Gotoh's proposal [30]. CYP3A163 displays the similar characteristic long sequences between helices F and G presenting two addi

• Injurious effects of cigarette smoke CS on human health are

  2020-11-17

  

  Injurious effects of cigarette smoke (CS) on human health are progressively being acknowledged both in animal and human studies. CS is a highly complex mixture that contains substantive amounts of toxic oxidants, nitric oxide, organic compounds, free radicals and microbial cell components including

14813 records 692/988 page Previous Next First page 上5页 691692693694695 下5页 Last page