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Data about the ability of non conventional
2020-08-08
Data about the ability of non-conventional ligands to operate class-A GPCRs have been accumulating. Specifically, increasing evidence indicates that oxysterols, oxidized derivatives of cholesterol, are involved in many activities that are not strictly associated with cholesterol metabolism and may a
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br Expression data suggest involvement of additional TRIMs
2020-08-08
Expression data suggest involvement of additional TRIMs in heart function Given the complexity of the cardiac function, involved molecular pathways and processes, and the fact that only a few of the TRIMs have thus far been shown to have a cardiac role, we hypothesized that there would be more TR
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As consequence all of them
2020-08-07
As consequence, all of them were efficiently characterized by the most important and crucial bonds with the biological target, as previously discussed for TKI258 I, and therefore experienced the most favourable predicted binding affinity profiles, being in agreement with the experimental data. In p
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Hysteresivity a measure of the ratio
2020-08-06
Hysteresivity, a measure of the ratio of the energy dissipated per cycle to the stored energy (Ludwig and Dallaire, 1994), is calculated as the ratio of elastance to resistance. Modification of the collagen-elastin fibre network might be the main determinant in the increase in hysteresivity (Rocco
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A notable feature in our findings
2020-08-06
A notable feature in our findings was the dissimilarity in the clustering ability of dimeric DDR1 ECD (DDR1-Fc) versus that of DDR2-Fc post-ligand binding, which was evident in the results from our AFM experiments. While the recombinant DDR1-Fc ECD spontaneously clustered to form high-order structur
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Drug induced toxicity is caused
2020-08-06
Drug-induced toxicity is caused either by parent compounds or by their reactive metabolites that are generated through biotransformation primarily in the liver (Srivastava et al., 2010). The cytochrome P450 (CYP) superfamily members contribute to approximately 80% of this process (Evans and Relling,
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Several pharmacokinetic and metabolic studies of
2020-08-06
Several pharmacokinetic and metabolic studies of TP in rats or rat liver microsomes have been reported, but most of them were focused on males only. (Liu et al., 2010) recently reported significant sex-specific toxicity of TP in rats, and ascribed it to the sex-differential hepatic metabolic activit
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In contrast the role of
2020-08-06
In contrast, the role of CRF2 receptors in anxiety behavior is less clear. For example, behavioral differences were noted in three recent CRF2 knockout studies. Using open-field center exploration as a measure, one study reported that CRF2 knockout mice showed increased center activity [27], another
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Epalrestat Here we report the cloning expression
2020-08-06
Here we report the cloning, expression and characterization of two CK1 isoforms of T. gondii and describe their sensitivity to a collection of structurally diverse CDK inhibitors. As predicted from earlier affinity-ligand purification studies [11], we have confirmed the sensitivity of one of these i
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Both DDRs are composed of an N terminal discoidin
2020-08-05
Both DDRs are composed of an N-terminal discoidin (DS) domain (Baumgartner et al., 1998), followed by a predicted DS-like domain (our unpublished results; Lemmon and Schlessinger, 2010), an extracellular juxtamembrane (JM) region, a transmembrane (TM) helix, a large cytosolic JM region, and a C-term
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In this issue Sidhu and colleagues develop inhibitors for
2020-08-05
In this issue, Sidhu and colleagues develop inhibitors for USP15, a member of the Ub-specific protease (USP) family of DUBs (Teyra et al., 2019). USP15 removes ubiquitin from a number of substrates, including transforming growth factor beta (TGF-β) receptor, as well as the E3 ligases MDM2, TRIM25, a
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cyproheptadine hcl br Epilepsy and treatment Refractory epil
2020-08-05
Epilepsy and treatment Refractory epilepsy severely impacts quality of life and neurodevelopment.14, 34 Median age of epilepsy onset is six weeks with 90% onset by three months.13, 14 Eighty percent of children with CDD have daily seizures and 20% have weekly to monthly seizures. Less than half (
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HBC australia Two cases with SERPINE FOSB fusion reported by
2020-08-05
Two cases with SERPINE1-FOSB fusion reported by Walther et al. [8] include a case with insertion of 61 nucleotides of SERPINE1 intron 1 between SERPINE exon 1 and FOSB exon 2. This fusion results in formation of putative translation start codon within FOSB exon 2. The other reported case with SERPIN
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Almorexant br Acknowledgements This study was supported by t
2020-08-04
Acknowledgements This study was supported by the Science Fund for Creative Research Groups of Gansu Province (Grant No.1210RJIA006) and the National Key Project of Scientific and Technical Supporting Program (No.2007BAD40B04) and was partially supported by the National Beef Cattle and Yak Industr
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br STAR Methods br Acknowledgments We would
2020-08-04
STAR★Methods Acknowledgments We would like to thank the DNA cloning, Protein Production, DNA sequencing facility, and mass spectrometry teams of the MRC Protein Phosphorylation and Ubiquitylation Unit for their support. We would like to thank Prof. Dario Alessi, Prof. Ronald Hay, Prof. Philip
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