• The ability of tumors to progress to more malignant phenotyp

  2019-05-16

  

  The ability of tumors to progress to more malignant phenotypes depends on tumor microenvironment. Blood capillaries, made up of endothelial cells, are usually static under physiological conditions but are induced to proliferate by direct exposure to angiogenic factors, for instance, vascular endothe

• GPCR Compound Library br Methods br Results br Discussion br

  2019-05-16

  

  Methods Results Discussion Conclusions Conflict of interest statement Introduction Pulmonary vein (PV) isolation using a conventional electrode catheter is an effective therapy for atrial fibrillation (AF) [1,2]. However, it requires a long procedure time and has occasionally been

• br Methods br Results br Discussion br

  2019-05-16

  

  Methods Results Discussion Conclusions Conflict of interest Acknowledgments We thank Mr. John Martin for his linguistic assistance, and Mr. Jiro Suto for technical assistance in developing the QRS-T subtraction program. This study was supported by the Fukuda Foundation for Medical

• The concept of metronomic chemotherapy began in the s

  2019-05-16

  

  The concept of metronomic chemotherapy began in the 1990s, when Kerbel showed chemotherapeutic agents may be able to target tumor vessel endothelial cells. In 2000, Browder et al demonstrated a more frequent, lower dose of cyclophosphamide, i.e. anti-angiogenic schedule, could induce response in tum

• br Methods br Results br Discussion Bisphosphonates reduce s

  2019-05-16

  

  Methods Results Discussion Bisphosphonates reduce skeletal morbidity in patients with advanced cancers involving bone and have become a recommended component of the multidisciplinary treatment of MBD [1]. However, bone-health benefits have not generally translated into significantly improve

• dna ligase We conducted a retrospective analysis

  2019-05-16

  

  We conducted a retrospective analysis to compare a BMD-alone strategy, versus BMD+FRAX® and BMD+FRAX®+TBS screening strategies. To our knowledge, this constitutes the first study to assess the relative contributions of FRAX® and TBS. In our cohort, FRAX®+BMD identified 9 (9%) additional patients at

• br Alternans and arrhythmogenesis in different clinical cond

  2019-05-16

  

  Alternans and arrhythmogenesis in different clinical conditions APD alternans, whether spatially concordant or discordant, can produce arrhythmias. For example, spatially concordant alternans themselves can produce 2:1 conduction block, thereby initiating re-entry [48]. Nevertheless, discordant a

• La cr nica es en las obras de

  2019-05-16

  

  La crónica es en las obras de Nájera, además de profusa, el género que imprimió mayor libertad creativa al contenido de sus temas, razón por la que sus múltiples intereses se vieron arropados más confortablemente en ella. La crónica de , otro de sus heterónimos más conocidos, fue entre otras cosas u

• The comparative consensus modelling approach used by Eaton

  2019-05-16

  

  The comparative consensus modelling approach used by Eaton and colleagues is now used frequently to justify the implementation of particular HIV interventions. However, this approach produces meaningful results only if the comparison is based on valid models. Most comparative consensus studies (incl

• br A new model of human wellbeing is emerging

  2019-05-15

  

  A new model of human wellbeing is emerging to guide humanity in the Anthropocene. In essence, it recognises that wellbeing depends on enabling every person to lead a life of dignity and opportunity, while safeguarding the integrity of Earth\'s life-supporting systems. The conceptual framework of s

• br In their Comment on the use

  2019-05-15

  

  In their Comment on the use of antenatal corticosteroids to reduce preterm infant deaths, Kishwar Azad and Anthony Costello advise “extreme caution” before scale-up in low-income settings. They emphasise maternal sepsis as a concern but cite only one trial in which dexamethasone resulted in a sign

• br La historia de los animales en el Nuevo

  2019-05-15

  

  La historia de los animales en el Nuevo Mundo La descripción de la ptio americana fue una tarea que realizaron algunos exploradores, soldados, funcionarios y religiosos como respuesta a la petición de información de las autoridades, deseosas de conocer la fauna y descubrir las propiedades de la n

• Una recopilaci n impresa del

  2019-05-15

  

  Una recopilación impresa del trabajo que realizó con su cámara, desde 1980 hasta 1986, fue publicado con el título: Guatemala: Eternal Spring, Eternal Tyranny en 1988. En 2010 reeditó el libro en español, el cual se difundió ampliamente en Guatemala como parte del proceso de recuperación histórica.

• br Current approaches to HIV prevention

  2019-05-15

  

  Current approaches to HIV prevention typically target people who are identified as, or self-identify, with being at risk. In Africa, 74% of new HIV infections are among adolescent girls aged 15–19 years, and AIDS-related illnesses are the leading cause of death among adolescent girls and women of

• In subgroup analysis of the types of hospice as

  2019-05-15

  

  In subgroup analysis of the types of hospice as classified by the administrative authorities (Table 3), there was a trend that the patients admitted to a public hospital had a higher rate of dying in a hospice than those admitted to a private hospital, especially in the military and veterans\' hospi

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