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Much of the focus of expert and public
2019-04-28
Much of the focus of expert and public attention has been on HIV treatment, including test and treat (ie, treatment as prevention) strategies. This is understandable. Treatment for HIV has become extraordinarily effective, costs have dropped substantially during the past two decades, and the potenti
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erk inhibitor br Substantial gains have been made globally f
2019-04-28
Substantial gains have been made globally for many of the health targets, but progress in the improvement of health has been unequal with respect to the most vulnerable populations, and major discrepancies persist across regions and socioeconomic status. Maternal immunisation is a unique opportu
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br CaMKII and heart failure progression CaMKII is a multifun
2019-04-26
CaMKII and heart failure progression CaMKII is a multifunctional serine–threonine kinase, phosphorylating target proteins. Under resting conditions, CaMKII is inactive. A rise in intracellular Ca2+ stimulates binding of Ca2+ to calmodulin (CaM), a ubiquitous Ca2+-binding protein. The Ca2+/CaM com
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br Material and methods br Results A total
2019-04-26
Material and methods Results A total of 4014 subjects were enrolled and registered during the initial recruitment dapagliflozin from September 2013 through March 2015. In total, 167 subjects were excluded because of missing pivotal data such as height, body weight, or age (date of birth). Fin
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However as the above results included patients
2019-04-26
However, as the above results included patients who underwent RMN ablation during its introduction to our center when physicians were still in the process of familiarization, we proceeded to compare fluoroscopy and procedural times in the most recent 50 patients undergoing ablation in each cohort.
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br The achievement of an AIDS free
2019-04-26
The achievement of an AIDS-free future will surely be a priority discussion topic at the upcoming International AIDS Society conference in Melbourne, Australia. The discovery that antiretroviral therapy (ART) limits HIV transmission follows several years of steady progress in controlling the epide
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We propose that the same geospatial statistical techniques
2019-04-25
We propose that the same geospatial statistical techniques can be applied to HIV. We used these techniques to estimate the number of HIV-infected individuals in Maseru (a health-care district in Lesotho) and establish their geographical location. The district of Maseru is a relatively large area, ab
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El trasfondo musical de la obra de
2019-04-25
El trasfondo musical de la obra de sor Juana Inés de la Cruz ha recibido la atención de connotados críticos, tanto del ámbito de la música como del de las letras. Quien parece haber inaugurado en toda forma esta veta crítica es Alfonso Méndez Plancarte en su admirable anotación de la obra de sor Jua
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El caso argentino sobre la literatura fant stica puede
2019-04-25
El caso argentino sobre la literatura fantástica puede ser interpretado de modo similar al de Mukarovsky, calculating dilution propósito de la obra de arte como hecho semiológico (estético/social): por un lado, se encuentra el signo poético, que Macedonio y Borges recuperan en la obra literaria medi
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ubiquitin De acuerdo con el historiador argentino la indepen
2019-04-25
De acuerdo con el historiador argentino, la independencia de las colonias españolas en América es el resultado de una degradación del poder español que había comenzado desde 1795. En primera instancia, el poder de la Corona española se hacía cada vez más lejano, pues la pérdida de la guerra de Españ
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In Alexandre de Figueiredo and colleagues take a step in
2019-04-25
In , Alexandre de Figueiredo and colleagues take a step in this direction with their time-series analysis of trends in vaccine coverage and a suite of socioeconomic and demographic factors across 190 countries over 30 years. The main aim was to gauge where and when ST 2825 coverage might fall below
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X rays commonly show a typical licked candy stick
2019-04-25
X-rays commonly show a typical licked candy stick appearance, based on concentric bone resorption. Common blood tests are usually normal, but bone alkaline phosphatase (BAP) may be elevated if a fracture occurred [8]. GSD is a diagnosis of exclusion. Diseases responsible of bone osteolysis such as i
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br Conclusions br Acknowledgements This work was
2019-04-25
Conclusions Acknowledgements This work was supported by Bloodwise, the International Myeloma Foundation and a Marie Curie Career Integration Grant from the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement n° [294160]. The osteoblast in normal bone physiology
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Gender transformative policy and cultural reforms are also
2019-04-25
Gender transformative policy and cultural reforms are also crucial to change prevailing norms and customs that devalue women and girls. Implementation and enforcement of non-discriminatory policies and practices that require gender equity in inheritance, property rights, education, and civil liberti
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br Tara Mangal and colleagues document the struggle
2019-04-25
Tara Mangal and colleagues document the struggle to eliminate polio in northern Nigeria. However, they overlook the importance of routine immunisation to polio eradication efforts. The investigators identified an association between the risk of contracting polio and oral polio vaccine unavailabil
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